Professor
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UTDRO Director of Research, Director of Clinical and Experimental Radiobiology Course
Marianne Koritzinsky
Scientist
MSc, PhD
Location
Princess Margaret Cancer Centre
Address
610 University Avenue, Toronto, Ontario Canada M5G 2M9
Clinical Interests
Molecular and cellular responses to hypoxia, Regulation of hypoxia-induced differential gene expression, Mechanisms of mRNA translation, Regulation of cancer cell metabolism, Regulation of endoplasmic reticulum homeostasis and secretory capacity, Identification of molecular markers of tumor hypoxia, Identification of molecular targets and pharmaceutical agents for cancer therapy
Accepting
Please contact Faculty Member for more information
Qualification
- MSc, Radiation Biophysics, Norwegian University of Science and Technology
- PhD, Biophysics, University of Oslo
Research Synopsis
Tumor hypoxia (poor oxygenation) limits efficacy of radio- and chemotherapy and promotes a more malignant phenotype. Our aim is to identify novel treatment strategies to mitigate the adverse effects of tumor hypoxia. To this end, we are exploiting pharmaceutical agents that affect the tumor microenvironment. We also aim to better understand how hypoxia regulates signaling and gene expression that confers altered metabolism, cancer cell survival and metastasis. See also www.wklab.org.
Appointments
- Director of Research, Department of Radiation Oncology, University of Toronto
- Director, Clinical and Experimental Radiobiology Course, Department of Radiation Oncology, University of Toronto
- Professor, Department of Radiation Oncology, University of Toronto
- Scientific Associate, Ontario Cancer Institute
- Full Member, Institute of Medical Science, University of Toronto