Marianne Koritzinsky MSc, PhD
Associate Professor
Contact Info
T: (416) 581-7841
F: (416) 946-2984
Website
Location
Princess Margaret Cancer Centre
610 University Avenue
Toronto, ON, M5G 2M9
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Degree/Qualification
MSc, Radiation Biophysics, Norwegian University of Science and Technology
PhD, Biophysics, University of Oslo
Appointments
Associate Professor, Department of Radiation Oncology, University of Toronto
Scientific Associate, Ontario Cancer Institute
Full Member, Institute of Medical Science, University of Toronto
Clinical Interests
Molecular and cellular responses to hypoxia, Regulation of hypoxia-induced differential gene expression, Mechanisms of mRNA translation, Regulation of cancer cell metabolism, Regulation of endoplasmic reticulum homeostasis and secretory capacity, Identification of molecular markers of tumor hypoxia, Identification of molecular targets and pharmaceutical agents for cancer therapy

Research/Teaching

Research Synopsis

Tumor hypoxia (poor oxygenation) limits efficacy of radio- and chemotherapy and promotes a more malignant phenotype. Our aim is to identify novel treatment strategies to mitigate the adverse effects of tumor hypoxia. To this end, we are exploiting pharmaceutical agents that affect the tumor microenvironment. We also aim to better understand how hypoxia regulates signaling and gene expression that confers altered metabolism, cancer cell survival and metastasis. See also www.wklab.org.

Publications and Awards

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