Clinical InterestsGynecologic tumors, Genitourinary tumors
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Tumor microenvironment in gynecologic tumors and prostate cancer
- Clinical-translational studies of hypoxia, interstitial fluid pressure (IFP) and tumor metabolism in cervix and prostate cancer. Approximately 600 patients have been accrued to prospective translational studies.
- Functional and metabolic imaging of human tumors using dynamic CT, dynamic MR and PET
- Bioluminescence imaging of metabolism in human tumors
- Pre-clinical and clinical-translational evaluation of the anti-angiogenic drug sorafenib in combination with radiotherapy. Phase I-II studies are currently accruing patients with cervix cancer or renal cell carcinoma. Both studies include extensive evaluation of imaging and tissue-based biomarkers prior to and during treatment.
- Mathematical modeling of vascularity, interstitial fluid dynamics and treatment response in tumors
Adaptive, image-guided radiotherapy for gynecologic tumors
- Assessment of cervix, uterine and normal tissue motion using 4D-MR imaging
- Evaluation of online daily imaging techniques for measuring target motion during radiotherapy
- Development of intensity modulated radiotherapy (IMRT) approaches for treating cervix cancer, including image-guided adaptive radiotherapy with interactive re-planning during fractionated treatment to compensate for changing tumor volume and position
- Development and implementation of MR-guided brachytherapy for cervix cancer, with treatment optimization in individual patients
Publications and Awards
Lim K, Kelly V, Stewart J, Xie J, Cho Y-B, Moseley J, Fyles A, Lundin A, Rehbinder H, Milosevic M. Pelvic radiotherapy for cervix cancer: Is what you plan actually what you deliver? Int J Radiat Oncol Biol Phys, 74(1), 304-12, 2009.
Zwahlen D, Jezioranski J, Chan P, Haider M, Cho Y-B, Yeung I, Levin W, Manchul Fyles A, Milosevic M. Magnetic resonance image-guided intracavitary brachytherapy for cervix cancer. Int J Radiat Oncol Biol Phys, 74(4), 1157-64. 2009.
Dinniwell R, Chan P, Czarnota G, Haider M, Fyles A, Jaffray D, Milosevic M. Pelvic lymph node topography for radiotherapy treatment planning from contrast-enhanced MR imaging. Int J Radiat Oncol Biol Phys, 74(3), 844-51, 2009.
Stewart J, Lim K, Kelly V, Xie J, Brock K, Moseley J, Cho Y-B, Fyles A, Lundin A, Rehbinder H, Löf J, Jaffray D, Milosevic M. Automated weekly replanning for intensity-modulated radiotherapy of cervix cancer. Int J Radiat Oncol Biol Phys, 2009.
Chopra S, Milosevic M, Haider M, Bristow R, Menard C. Comparing oxygen-sensitive MRI (BOLD R2*) with oxygen electrode measurements: A pilot study in men with prostate cancer. Int J Radiat Biol, 85(9), 805-13, 2009.
Molavian H, Kohandel M, Milosevic M, Sivaloganathan S. Fingerprint of cell metabolism in the lack of correlation between the interstitial pH and pO2 in solid tumors. Cancer Res, 69(23), 9141-7, 2009.