Michael MilosevicMD, FRCPC

Contact Info

T. (416) 946-2932
F. (416) 946-2227


Princess Margaret Cancer Centre
610 University Avenue
ON, M5G 2M9

Clinical Interests

Gynecologic tumors, Genitourinary tumors


Please contact Faculty Member for more information


BASc, Engineering and Management, University of Waterloo
MD, Queen’s University
FRCPC, Radiation Oncology


UT-DRO Vice Chair, Research
Professor, Department of Radiation Oncology, University of Toronto
Associate Director, Radiation Medicine Program, Princess Margaret Hospital/University Health Network, Toronto
Gynecologic cancer site leader, Radiation Medicine Program, Princess Margaret Hospital/University Health Network, Toronto
Director of Research, Radiation Medicine Program, Princess Margaret Hospital/University Health Network, Toronto
Director, STTARR Core III, University Health Network, Toronto
Biomechanical Research Group, Department of Applied Mathematics, University of Waterloo
Chair, Canadian Partnership for Quality Radiotherapy (CPQR)


Research Synopsis:

Tumor microenvironment in gynecologic tumors and prostate cancer


  • Clinical-translational studies of hypoxia, interstitial fluid pressure (IFP) and tumor metabolism in cervix and prostate cancer. Approximately 600 patients have been accrued to prospective translational studies.
  • Functional and metabolic imaging of human tumors using dynamic CT, dynamic MR and PET
  • Bioluminescence imaging of metabolism in human tumors
  • Pre-clinical and clinical-translational evaluation of the anti-angiogenic drug sorafenib in combination with radiotherapy. Phase I-II studies are currently accruing patients with cervix cancer or renal cell carcinoma. Both studies include extensive evaluation of imaging and tissue-based biomarkers prior to and during treatment.
  • Mathematical modeling of vascularity, interstitial fluid dynamics and treatment response in tumors


Adaptive, image-guided radiotherapy for gynecologic tumors

  • Assessment of cervix, uterine and normal tissue motion using 4D-MR imaging
  • Evaluation of online daily imaging techniques for measuring target motion during radiotherapy
  • Development of intensity modulated radiotherapy (IMRT) approaches for treating cervix cancer, including image-guided adaptive radiotherapy with interactive re-planning during fractionated treatment to compensate for changing tumor volume and position
  • Development and implementation of MR-guided brachytherapy for cervix cancer, with treatment optimization in individual patients


Publications and Awards

Recent Publications

Lim K, Kelly V, Stewart J, Xie J, Cho Y-B, Moseley J, Fyles A, Lundin A, Rehbinder H, Milosevic M. Pelvic radiotherapy for cervix cancer: Is what you plan actually what you deliver? Int J Radiat Oncol Biol Phys, 74(1), 304-12, 2009.

Zwahlen D, Jezioranski J, Chan P, Haider M, Cho Y-B, Yeung I, Levin W, Manchul Fyles A, Milosevic M. Magnetic resonance image-guided intracavitary brachytherapy for cervix cancer. Int J Radiat Oncol Biol Phys, 74(4), 1157-64. 2009.

Dinniwell R, Chan P, Czarnota G, Haider M, Fyles A, Jaffray D, Milosevic M. Pelvic lymph node topography for radiotherapy treatment planning from contrast-enhanced MR imaging. Int J Radiat Oncol Biol Phys, 74(3), 844-51, 2009.

Stewart J, Lim K, Kelly V, Xie J, Brock K, Moseley J, Cho Y-B, Fyles A, Lundin A, Rehbinder H, Löf J, Jaffray D, Milosevic M. Automated weekly replanning for intensity-modulated radiotherapy of cervix cancer. Int J Radiat Oncol Biol Phys, 2009.

Chopra S, Milosevic M, Haider M, Bristow R, Menard C. Comparing oxygen-sensitive MRI (BOLD R2*) with oxygen electrode measurements: A pilot study in men with prostate cancer. Int J Radiat Biol, 85(9), 805-13, 2009.

Molavian H, Kohandel M, Milosevic M, Sivaloganathan S. Fingerprint of cell metabolism in the lack of correlation between the interstitial pH and pO2 in solid tumors. Cancer Res, 69(23), 9141-7, 2009.

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